Critical for human development and health, neural crest cells arise early in the development of vertebrates. They migrate extensively inside the embryo, and differentiate to give rise to a wide array of diverse derivatives. Accessing these cells, however, is difficult. Work done by a research team now provides a fast, simple and cost-effective method to generate neural crest cells, facilitating research in basic sciences and clinical applications alike.
Injury to the anterior cruciate ligament (ACL) in the knee frequently leads to early-onset osteoarthritis, a painful condition that can occur even if the patient has undergone ACL reconstruction to prevent its onset. A new review looks at the ability of two different reconstruction techniques to restore normal knee motion and potentially slow degenerative changes.